Osteoporosis Osteoporosis is a systemic skeletal disease characterized by a reduction of bone density and altred bone quality, with increased fracture risk.
Osteoporosis is a systemic skeletal disease characterized by a reduction of
bone density and altred bone quality, with increased fracture risk.
A systemic skeletal disease
Reduction of bone density.
Altered bone quality.
Increased fracture risk .
In developed countries, the lifetime risk for osteoporotic fractures at the wrist, hip or spine is 30% to 40%, very close to that for coronary heart disease.
An age-related disease
Osteoporosis is an age related
disease and becomes more common
in advanced age.
Meaning of fractures
Elderly suffering with femoral fractures
die within a year (15-25%) or become
dependent (50%). A single vertebral fracture
doubles the risk of subsequent femoral fracture
within a year. Multiple vertebral fractures impair
patients’ quality of life and increase mortality.
Loss of indipendence
The innovative solution
Novaicos aims to reduce the fracture
incidence with an innovative pharmacological
approach, is developing a new biological drug,
biocompatible and modulable, reversible
ICOS-Fc inhibits bone resorpition
and allows bone formation.
and activity in vitro
ICOS-Fc directly inhibits the bone resorbing
cells (osteoclasts) without toxic effect.
of bone erosion
ICOS-Fc is able to restore bone structure
in vivo in different mice models
selective inhibits resorbing
quick wash out (20 days)
allows bone remodelling
Scientific Road Map
A - Pre clinical data on osteoporosis completed
B - Development of new formulations
C - GMP Compounr obtained
D - Phase 1 Clinical Study
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