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      R&D

      Osteoporosis
      is a systemic skeletal disease characterized by a reduction of bone density and altred bone quality, with increased fracture risk.

      Osteoporosis is a systemic skeletal disease characterized by a reduction of bone  density and altred bone quality, with increased fracture risk. 

      A systemic skeletal disease characterized by:

      • Reduction of bone density.
      • Altered bone quality.
      • Increased fracture risk .

      The Number: 

      In developed countries, the lifetime risk for osteoporotic fractures at the wrist, hip or spine is 30% to 40%, very close to that for coronary heart disease.

      An age-related disease 

      Osteoporosis is an age related disease and becomes more common in advanced age.

      Meaning of fractures

       Elderly suffering with femoral fractures die within a year (15-25%) or become dependent (50%). A single vertebral fracture doubles the risk of subsequent femoral fracture within a year. Multiple vertebral fractures impair patients’ quality of life and increase mortality.

      Socioeconomic burden:

      • Inhospital stay 
      • Rehabiltation costs
      • Loss of indipendence
      • Caregiver burden
      • Increased mortality

      The innovative solution

      Novaicos aims to reduce the fracture incidence with an innovative pharmacological approach, is developing a new biological drug, biocompatible and modulable, reversible and efficacious.

      ICOS-Fc work

      ICOS-Fc inhibits bone resorpition and allows bone formation.

       

      ICOS-Fc inhibit osteoclast  formation and activity in vitro

      ICOS-Fc directly inhibits the bone resorbing cells (osteoclasts) without toxic effect.

       

      ICOS-Fc activity in models of bone erosion. 

      ICOS-Fc is able to restore bone structure in vivo in different mice models
      of osteoporosis.

       

      On Target

      selective inhibits resorbing osteoclats

      On Time

      quick wash out (20 days) allows bone remodelling