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Osteoporosis
Osteoporosis is a systemic skeletal disease characterized by a reduction of
bone density and altred bone quality, with increased fracture risk.
A systemic skeletal disease
characterized by:
Reduction of bone density.
Altered bone quality.
Increased fracture risk .
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The number
In developed countries,
the lifetime risk for osteoporotic fractures at the wrist,
hip or spine is 30% to 40%,
very close to that for coronary heart disease.
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An age-related disease
Osteoporosis is an age related
disease and becomes more common
in advanced age.
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Meaning of fractures
Elderly suffering with femoral fractures
die within a year (15-25%) or become
dependent (50%). A single vertebral fracture
doubles the risk of subsequent femoral fracture
within a year. Multiple vertebral fractures impair
patients’ quality of life and increase mortality.
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Socioeconomic burden:
Inhospital stay
Rehabiltation costs
Loss of indipendence
Caregiver burden
Increased mortality
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The innovative solution
Novaicos aims to reduce the fracture
incidence with an innovative pharmacological
approach, is developing a new biological drug,
biocompatible and modulable, reversible
and efficacious.
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ICOS-Fc work
ICOS-Fc inhibits bone resorpition
and allows bone formation.
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ICOS-Fc inhibit
osteoclast formation
and activity in vitro
ICOS-Fc directly inhibits the bone resorbing
cells (osteoclasts) without toxic effect.
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ICOS-Fc activity
in models
of bone erosion
ICOS-Fc is able to restore bone structure
in vivo in different mice models
of osteoporosis.
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On Target
selective inhibits resorbing
osteoclats
On Time
quick wash out (20 days)
allows bone remodelling
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Scientific Road Map
A - Pre clinical data on osteoporosis completed
B - Development of new formulations
C - GMP Compounr obtained
D - Phase 1 Clinical Study