Osteoporosis

Osteoporosis is a systemic skeletal disease characterized by a reduction of
bone density and altred bone quality, with increased fracture risk.

A systemic skeletal disease
characterized by:
Reduction of bone density.
Altered bone quality.
Increased fracture risk .

The number

In developed countries,
the lifetime risk for osteoporotic fractures at the wrist,
hip or spine is 30% to 40%,
very close to that for coronary heart disease.

An age-related disease

Osteoporosis is an age related
disease and becomes more common
in advanced age.

Meaning of fractures

Elderly suffering with femoral fractures
die within a year (15-25%) or become
dependent (50%). A single vertebral fracture
doubles the risk of subsequent femoral fracture
within a year. Multiple vertebral fractures impair
patients’ quality of life and increase mortality.

Socioeconomic burden:

Inhospital stay
Rehabiltation costs
Loss of indipendence
Caregiver burden
Increased mortality

The innovative solution

Novaicos aims to reduce the fracture
incidence with an innovative pharmacological
approach, is developing a new biological drug,
biocompatible and modulable, reversible
and efficacious.

ICOS-Fc work

ICOS-Fc inhibits bone resorpition
and allows bone formation.

ICOS-Fc inhibit
osteoclast formation
and activity in vitro

ICOS-Fc directly inhibits the bone resorbing
cells (osteoclasts) without toxic effect.

ICOS-Fc activity
in models
of bone erosion

ICOS-Fc is able to restore bone structure
in vivo in different mice models
of osteoporosis.

On Target

selective inhibits resorbing
osteoclats

On Time

quick wash out (20 days)
allows bone remodelling

Scientific Road Map

A - Pre clinical data on osteoporosis completed
B - Development of new formulations
C - GMP Compounr obtained
D - Phase 1 Clinical Study